Last updated: June 1st, 2018
Thank you for your interest in MySleepInsight, a MyVytalics product. This Informed Consent gives you information to help you decide if you would like to utilize the MySleepInsight application. Please read this Consent Form carefully. To get started you must agree to the provisions in the MySleepInsight Informed Consent (below).
- What does taking the MySleepInsight DNA Test involve?
- What’s the science behind the service?
- Does MySleepInsight tell me about my health or ancestry?
- What are the potential risks to taking the MySleepInsight DNA Test?
- What are the potential benefits to taking the MySleepInsight DNA Test?
- How does MySleepInsight keep my genetic information confidential and private?
- Who can I contact if I have questions?
- What does taking the MySleepInsight DNA Test involve?
MySleepInsights is a web-based application that delivers information about how your genetic makeup affects your sleep patterns. The application also includes other optional tools such sleep feedback from activity trackers.
Here is what you can expect if you decide to order MySleepInsights:
- If you have not already had your DNA sequenced by Helix (our partner laboratory), Helix will send you an easy-to-use saliva collection kit in the mail, so you can submit a sample of your saliva for DNA sequencing.
- Helix will provide MyVytalics with your genetic information for a specific set of genes that relate to sleep, chronotype, and response to nutrients. MyVytalics applies an algorithm to the genetic information to generate your MySleepInsights results.
- MyVytalics notifies you by email when your results are ready. You can access your results and most of MySleepInsights’s features using your web browser on almost any device.
What’s the science behind the service?
Your DNA is in each one of your cells. DNA is a thin, long molecule; if stretched out, the DNA in each of your cells would be over six feet long. DNA is made up of a string of chemicals known as bases. There are four types of bases, called A, C, G and T for short. A string of just over 3 billion of these bases makes the human DNA, also called the “human genome.” The order of these bases in the long DNA molecule is called the “DNA Sequence.” The order of these bases spell out the instructions to make you. Amazingly, 99.9% of your DNA is identical to any other human on the planet. However, this small difference in DNA sequence between individuals is what helps make us unique.
Scientific studies suggest that about a third of the variation in sleep patterns between individuals is due to genetics.1 Scientific data suggest that sleep patterns such insomnia, chronotype, sleep duration have a genetic component.2-4 In addition, genetics also has an impact on the response to nutrients and several common foods have been implicated on sleep patterns.5-13
The scientists at MyVytalics reviewed dozens of studies involving tens of thousands of people from a variety of ethnic backgrounds. Of the genetic variants identified in the studies, they selected the ones that were most strongly associated with sleep. MyVytalics reports your DNA variants and their potential association to your sleep profile. Some of these variants may have an influence on insomnia predisposition in males and females sleep duration, daytime napping, easy of waking up, chronotype, and snoring. MyVytalics also reports on DNA variants associated with Vitamins D and B12, caffeine, and alcohol.
Does MySleepInsights tell me about my health or ancestry?
The DNA analysis used to power the MySleepInsights service does not look at or report genetic variations that have a known impact on your health or any medical conditions. All MySleepInsights results are for information purposes only and should not be used for any health-related interpretations or decisions. Further, the MySleepInsights service does not provide information about your ancestry.
What are the potential risks to taking the MySleepInsights DNA Test?
The risks of taking the MySleepInsights DNA Test are minimal. There are no known risks of providing a saliva sample.
As with any information online, there is a risk of loss of privacy and confidentiality of your personal information and survey responses. To protect your information, MyVytalics uses stringent security protections to minimize the risk of unapproved access to user accounts. If you disclose your account password to others, they may be able to access your account and your information.
When MyVytalics scientists publish results from their research, they may include your genetic and survey data but only as part of a summary of results to minimize the chance that your personal information will be exposed.
Genetics is an evolving science, so it may be that we learn something unexpected about the sleep, circadian cycle and nutrition response-related genes that we analyze that you may not want to know.
There may be risks that are not known at this time.
What are the potential benefits to taking the MySleepInsights DNA Test?
Taking the MySleepInsights DNA Test will allow you to learn more about how your genetic makeup may affect your sleep patterns. By tracking your sleep, mood, and activity data within the application, you may learn new insights about how your behavior affects your sleep and your circadian cycle. You may also choose to engage in community activities, where you can share your MySleepInsights results through social media or other means. All community activities are completely voluntary, and participation can be stopped at any time.
If you have not yet had your DNA sequenced by Helix, your MySleepInsights purchase will give you access to the Helix marketplace, where you can purchase more DNA-powered products from a variety of categories like fitness, nutrition, and entertainment.
How does MyVytalics keep my genetic information confidential and private?
All genetic data is kept in an encrypted storage system and access is tightly controlled, in accordance with industry practices. MyVytalics will not share any of your identifying information with any external party, without your explicit consent. MyVytalics will utilize and share de-identified, pooled customer data for product research and/or product improvement purposes only with explicit user’s consent. Identification of your individual-level data from pooled customer data would be extremely difficult, but it is possible that a third party that has obtained some of your genetic data could compare that partial data to the pooled customer data and infer some of your other personal information. MyVytalics will take reasonable precautions to minimize the risk of your personal identifying information being exposed
Who can I contact if I have questions?
If you have any questions about MyVytalics’s products and services, you may contact us by email at info@MyVytalics.com.
By checking the box next to “I have read and understand the MySleepInsights Informed Consent” during the MySleepInsights registration process, you consent and agree to the following:
- You are at least 18 years old.
- You allow Helix to share with MyVytalics your genetic information for the specific genetic markers required to provide MySleepInsights results.
- You allow MyVytalics to retain your MySleepInsights data as part of MyVytalics’s secure database, for use by MyVytalics or its research affiliates, to improve and expand services. If any commercial product is developed because of the use of your data, there will be no financial benefit to you.
You may receive communications from MyVytalics to keep you current on new information relevant to your MySleepInsights results or other products that may be of interest to you. You may choose to opt out of receiving these emails.
1 Dauvilliers, Y. et al. Family studies in insomnia. J Psychosom Res 58, 271-278, doi:10.1016/j.jpsychores.2004.08.012 (2005).
2 Hammerschlag, A. R. et al. Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits. Nat Genet 49, 1584-1592, doi:10.1038/ng.3888 (2017).
3 Jansen, P. R. Genome-wide Analysis of Insomnia (N=1,331,010) Identifies Novel Loci and Functional Pathways, <https://www.biorxiv.org/content/early/2018/01/30/214973> (2018).
4 Lane, J. M. et al. Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits. Nat Genet 49, 274-281, doi:10.1038/ng.3749 (2017).
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6 Clark, I. & Landolt, H. P. Coffee, caffeine, and sleep: A systematic review of epidemiological studies and randomized controlled trials. Sleep Med Rev 31, 70-78, doi:10.1016/j.smrv.2016.01.006 (2017).
7 Ghotbi, R. et al. Comparisons of CYP1A2 genetic polymorphisms, enzyme activity and the genotype-phenotype relationship in Swedes and Koreans. Eur J Clin Pharmacol 63, 537-546, doi:10.1007/s00228-007-0288-2 (2007).
8 Jorgenson, E. et al. Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study. Mol Psychiatry 22, 1359-1367, doi:10.1038/mp.2017.101 (2017).
9 Majid, M. S., Ahmad, H. S., Bizhan, H., Mohammad Hosein, H. Z. & Mohammad, A. The effect of vitamin D supplement on the score and quality of sleep in 20-50 year-old people with sleep disorders compared with control group. Nutr Neurosci, 1-9, doi:10.1080/1028415X.2017.1317395 (2017).
10 Massa, J. et al. Vitamin D and actigraphic sleep outcomes in older community-dwelling men: the MrOS sleep study. Sleep 38, 251-257, doi:10.5665/sleep.4408 (2015).
11 McCarty, D. E., Chesson, A. L., Jr., Jain, S. K. & Marino, A. A. The link between vitamin D metabolism and sleep medicine. Sleep Med Rev 18, 311-319, doi:10.1016/j.smrv.2013.07.001 (2014).
12 Tanaka, T. et al. Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations. Am J Hum Genet 84, 477-482, doi:10.1016/j.ajhg.2009.02.011 (2009).
13 Wang, T. J. et al. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet 376, 180-188, doi:10.1016/S0140-6736(10)60588-0 (2010).